This article describes developments in nursing research in the Midwest and events that led to regionalization of nursing activities. It emphasizes the special characteristics of the Midwest that have influenced nursing research, results of federal support programs for nursing research, and centralization of research effort in some schools of nursing. It traces the events leading to regionalization of nursing research, the formation of the Midwest Alliance in Nursing, establishment of the Midwest Nursing Research Society, and anticipation of centralization of regional nursing activities under the aegis of MAIN.