Calcium-dependent release of acetyl-coenzyme A from liver mitochondria
- 1 February 1983
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 61 (2) , 154-158
- https://doi.org/10.1139/y83-023
Abstract
Calcium ions (10 μM) enhance the permeability of the hepatic inner mitochondrial membrane to acetyl-CoA (and CoA). This effect is suppressed by the absence of phosphate ions or by the presence of EGTA, La3+, or ruthenium red. Exposure of mitochondria to Ca2+ for short intervals of time (e.g., 10 min) results in a reversible permeability change with release of acetyl-CoA and retention of sensitivity to EGTA. It is suggested that conditions resulting in an increase of the calcium ion concentration in the cytoplasm may thereby increase the rate of transfer of acetyl-CoA from the mitochondria to the cytoplasm.This publication has 1 reference indexed in Scilit:
- [15] Isolation of liver or kidney mitochondriaPublished by Elsevier ,1967