The Effect of Birth on the Maturation of Hepatic Cytochrome(s) P-450 Mono-Oxygenase and Tyrosine Aminotransferase Activities in the Guinea Pig

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Abstract
Mixed coat guinea pigs delivered by Caesarian section 5 days before term were compared to spontaneously delivered full-term animals with respect to the postnatal maturation of hepatic mono-oxygenase activity in vitro toward aniline and p-chloro-N-methylaniline. Tyrosine aminotransferase activity was studied in the same preparations as a positive control for birth-related phenomena. Mono-oxygenase activities toward both substrates increased significantly in both premature and full-term animals during the first 3 postnatal days and approached adult values 72 h after birth. The maturation of tyrosine aminotransferase activity occurred in a qualitatively similar fashion. The mechanism through which birth initiates the maturation of drug oxidative capacity is unresolved; the gestational age at which competence to respond to the event of birth is acquired, remains undefined.

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