Oxfendazole—anthelmintic activity in egyptian goats artificially infected with gastrointestinal nematodes

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Abstract
The recently developed benzimidazole anthelmintic, oxfendazole, was tested against artificial nematode infestations in Egyptian goats using oral dosing at 4.5 and 2.8 mg/kg. A 100% clearance of mature and immatureHaemonchus contortus, Trichostrongylus axei, Ostertagia circumcincta, Cooperia curticei, Bunostomum trigonocephalum andChabertia ovina was obtained at the 4.5 mg/kg level. Very high levels of clearance against the mature worms were obtained at 2.8 mg/kg but the drug was less effective against immature worms at the lower dose rate. PCV, haemoglobin concentration and total erythrocyte counts declined after infection but became significantly (PHaemonchus contortus, Trichostrongylus axei, Ostertagia circumcincta, Cooperia curticei, Bunostomum trigonocephalum et deChabertia ovina, adultes et larves. De très hauts niveaux d'élimination des vers adultes ont été atteints à la dose de 2,8 mg/kg mais l'efficacité du produit était moindre en ce qui concerne les larves à cette dernière dose. Le culot cellulaire, la concentration d'hémoglobine et les numérations totales dérythrocytes diminuaient lors de l'infestation mais s'élevaient de façon significative (PHaemonchus contortus, Trichostrongilus axei, Ostertagia circumcincta, Cooperia curticei, Bunostomun trigonocephalum yChabertia ovina. La dosis de 2.8 mg/kg de peso, tuvo una buena efectividad contra parásitos adultos, pero fué poco efectiva contras las formas inmaduras. El hematocrito, la hemoglobina y el total de eritrocitos disminuyeron despues de la infección oral, pero aumentaron significativamente despues del tratamiento.