Characterization of an amyloid beta precursor protein that binds heparin and contains tyrosine sulfate.
- 1 March 1989
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 86 (6) , 2066-2069
- https://doi.org/10.1073/pnas.86.6.2066
Abstract
A secreted form of the amyloid .beta. protein precursor was isolated from the growth conditioned medium of the PC12 sympathetic nerve-like cell line. This protein is recognized by an antiserum that detects a protein of 140 kDa and a less abundant species of 115 kDa on NaDodSO4/acrylamide gels. The amyloid precursor proteins contain O-linked sugars and tyrosine sulfate and bind to the glycosaminoglycan heparin. These results suggest a role for extracellular sulfated glycoproteins in the pathogenesis of Alzheimer disease.This publication has 19 references indexed in Scilit:
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