Prevalence and genetic aspects of deaf mutism in Shanghai.
- 1 October 1987
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 24 (10) , 589-592
- https://doi.org/10.1136/jmg.24.10.589
Abstract
Two hundred and eighty-five cases of congenital deaf mutism were ascertained in a population of 483,611 in Zhabei District in Shanghai. The prevalence was 0.059% (1:1697). Inherited cases accounted for 84.83% of all cases. The mode of inheritance was autosomal recessive with complete penetrance and heterogeneity (consisting of at least five different loci). The fitness was 77.63%, the coefficient of selection was 0.2237, the mutation rate was 1.119 .times. 10-4 mutation/gamete, and no heterozygote advantage was proven.This publication has 5 references indexed in Scilit:
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