5-Hydroxytryptamine Injected Intraventricularly Fails to Influence the Brain Water Content

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Abstract
Measurement of the content of brain water and electrolytes after the intraventricular administration of 5-hydroxytryptamine in rats, with and without exposure to osmotic stress, failed to show water accumulation in the brain parenchyma. It is suggested that elevation of serotonin in the cerebrospinal fluid-resembling pathological situations such as subarachnoid hemorrhage-does not play a primary role in brain edema formation.

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