Biological monitoring of exposure to styrene by analysis of combined urinary mandelic and phenylglyoxylic acids

1 November 1978

journal article
research article
Published by Taylor & Francis in Aihaj Journal

Vol. 39 (11) , 873-879
https://doi.org/10.1080/0002889778507877

Abstract

Human volunteers were exposed in an experimental chamber to styrene (environmental pollutant, 4 or 8 h at 40-200 ppm) to obtain a quantitative relationship between exposure and urinary elimination of the metabolites mandelic and phenylglyoxylic acids (MA and PGA). For the analysis of PGA a new GC[gas chromatographic]-method was used, based on reductive transformation of the relatively instable PGA into MA, which is stable enough for shipping and handling until final processing. The analysis of the post-exposure elimination shows that spot urine sampled in the morning after exposure and analysed for the sum of MA and PGA is the most reliable index for reflecting a preceding exposure to styrene.

Keywords

This publication has 3 references indexed in Scilit:

Action of styrene and its metabolites styrene oxide and styrene glycol on activities of xenobiotic biotransformation enzymes in rat liver in vivo
Toxicology and Applied Pharmacology, 1976
Human exposure to styrene
Internationales Archiv für Arbeitsmedizin, 1976
Human exposure to styrene
Internationales Archiv für Arbeitsmedizin, 1976