Glyoxalase and methylglyoxal in thiamine-deficient rats

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Abstract
Methylglyoxal is present in the urine of thiamine-deficient rats. Restoration of thiamine to the diet caused its disappearance. The glyoxalase activity of the livers of thiamine-deficient rats was much lower than in normal animals, and was restored to normal by including thiamine in the diet. Methylglyoxal was produced by liver suspensions from thiamine-deficient rats when hexose diphosphate was added. It did not accumulate in normal liver suspensions because the latter contained glyoxalase.

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