The Effect of 5,5'-diphenylhydantoin on the Metabolism of 17β-estradiol by Rat Oral Mucosa

Abstract
Systemic pretreatment of rats with 5,5'-diphenylhydantoin (DPH) or its addition into an in vitro assay increases microsomal hydroxylation of 17β-estradiol. This increase depends on the concentration of DPH in the microsomal cell compartment.