Methylphenidate Blood Plasma Levels In the Horse Determined By Derivative Gas-Liquid Chromatography--Electron Capture

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Abstract
An acylated derivative of methylphenidate with high detection sensitivity is formed following a reduction procedure with LiAIH4. The derivative is analyzed by gas-liquid chromatography using an electron capture detector. The preparation of the derivative is rapid and simple. Drugs such as cocaine, atropine, and indomethacin also form sensitive derivatives when subjected to “reductive fragmentation” followed by acylation, as described in this paper.