Immunophenotypic and clinical features of T‐cell receptor γδ+ T‐lineage acute lymphoblastic leukaemia
- 1 June 1998
- journal article
- research article
- Published by Wiley in British Journal of Haematology
- Vol. 101 (4) , 753-755
- https://doi.org/10.1046/j.1365-2141.1998.00774.x
Abstract
The immunophenotypic and clinical features of TCR-γδ+ T-lineage acute lymphoblastic leukaemia (T-ALL) were prospectively analysed in 52 children with membrane CD3+ T-ALL. We observed a relatively high incidence of TCR-γδ+ T-ALL (26/52 patients). Leukaemic blasts from 22 children demonstrated TCR-αβ positivity, and simultaneous expression of the TCR-β and -δ chain was found in four children. Clinical and haematological features of TCR-αβ and γδ+ T-ALL did not differ significantly, except that haemoglobin levels were significantly lower in TCR-γδ+ cases. Event-free survival at 4 years was significantly better in TCR-γδ+ compared with TCR-αβ+ T-ALL, but expression of TCR molecules did not emerge as an independent prognostic factor in multivariate analysis.Keywords
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