Brain elasticity changes with ventriculomegaly

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Abstract
The pressure-volume relationship of brain elasticity was determined in 32 patients during servo-controlled variable-rate lumbar infusions to measure net CSF absorptive capacity. Several indices were used to estimate ventricular size from computerized tomography scans. A linear relationship existed between ventricular size and the elasticity slope relating the natural log of pressure to volume. A hydrocephalic patient should show a greater intracranial pulse amplitude at a given pressure than does a patient with normal-sized ventricles. Although these elasticity changes may result from ventriculomegaly, the pressure-volume elasticity relationship may be of etiological importance in disorders of the CSF system.