Role of Inducible Nitric Oxide Synthase in Resistance toMycobacterium lepraein Mice
Open Access
- 1 September 2000
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 68 (9) , 5462-5465
- https://doi.org/10.1128/iai.68.9.5462-5465.2000
Abstract
The manifestation of leprosy in humans is largely determined by host immunity toMycobacterium lepraeand is a model for immunoregulation in a human disease. However, animal models available for exploration of the leprosy spectrum are inadequate. This study exploredM. lepraeinfection in mice deficient in inducible nitric oxide synthase, and this report describes elements resembling borderline tuberculoid leprosy in humans.Keywords
This publication has 20 references indexed in Scilit:
- Inhibition of metabolism and growth of Mycobacterium leprae by gamma irradiation.2000
- Reactive oxygen and reactive nitrogen intermediates in innate and specific immunityCurrent Opinion in Immunology, 2000
- NOS2‐derived nitric oxide regulates the size, quantity and quality of granuloma formation in Mycobacterium avium‐infected mice without affecting bacterial loadsImmunology, 1999
- NITRIC OXIDE AND MACROPHAGE FUNCTIONAnnual Review of Immunology, 1997
- Comparison of the roles of reactive oxygen and nitrogen intermediates in the host response to Mycobacterium tuberculosis using transgenic miceTubercle and Lung Disease, 1997
- Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death.Proceedings of the National Academy of Sciences, 1995
- Differential mechanisms of intracellular killing ofMycobacterium aviumandListeria monocytogenesby activated human and murine macrophages. The role of nitric oxideClinical and Experimental Immunology, 1993
- Killing of virulent Mycobacterium tuberculosis by reactive nitrogen intermediates produced by activated murine macrophages.The Journal of Experimental Medicine, 1992
- The growth of Mycobacterium leprae in nude miceLeprosy Review, 1983
- Growth of Mycobacterium leprae and M. marinum in congenitally athymic (nude) miceNature, 1976