Development of Daptomycin Resistance In Vivo in Methicillin-Resistant Staphylococcus aureus
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Open Access
- 1 October 2005
- journal article
- case report
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 43 (10) , 5285-5287
- https://doi.org/10.1128/jcm.43.10.5285-5287.2005
Abstract
Daptomycin is a new lipopeptide antibiotic that is rapidly bactericidal against Staphylococcus aureus. We report daptomycin resistance and treatment failure in 2 patients with osteomyelitis due to methicillin-resistant S. aureus. Disk diffusion susceptibility testing failed to detect resistance. Daptomycin at high concentration retained bactericidal activity against resistant isolates.Keywords
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