A Radioimmunoassay for Norethindrone. II. Plasma Levels in Hypertensive and Nomotensive Oral Contraceptive Users
- 31 December 1975
- journal article
- research article
- Published by Taylor & Francis in Analytical Letters
- Vol. 9 (1) , 91-103
- https://doi.org/10.1080/00032717608059083
Abstract
A sensitive radioimmunoassay for measurement of norethindrone (N) in blood plasma has been developed. The coefficient of variation within the assay and between assays was 7 and 13.5% respectively. The procedural blanks were negligible, and recovery was approximately 81.8%. Blood plasma levels of N in 20 normotensive and 6 hypertensive women who were ingesting oral contraceptives (OCs) were measured, and the results indicate that the subjects who became hypertensive while taking OCs had significantly higher levels of N compared with normotensive OC users (p < .001).Keywords
This publication has 4 references indexed in Scilit:
- The metabolic clearance rate and urinary excretion of oral contraceptive drugsAmerican Journal of Obstetrics and Gynecology, 1974
- Radioimmunoassay of norethindrone: Peripheral plasma levels after oral administration to humans and rhesus monkeysContraception, 1974
- Oral contraceptives and hypertension. An epidemiological survey.Heart, 1972
- The effect of intrauterine devices, oral contraceptives, estrogens, and progestogens on blood pressureAmerican Journal of Obstetrics and Gynecology, 1972