Inhibition of metastasis by inhibition of tumor-derived CCL5
- 1 January 2005
- journal article
- Published by Springer Nature in Breast Cancer Research and Treatment
- Vol. 89 (2) , 209-212
- https://doi.org/10.1007/s10549-004-5328-3
Abstract
To determine whether tumor-derived CCL5 contributes to the metastatic potential of murine mammary carcinoma, we used the 4T1 tumor which spontaneously metastasizes and constitutively produces CCL5. Mice bearing 4T1 that expressed less CCL5 had significantly fewer lung and liver metastasis. The decrease in tumor-derived CCL5 also correlated with decreased cathepsin L, MMP-2, MMP-3, MMP-10 and MMP-17 gene expression. Thus, inhibition of tumor-derived CCL5 can impact the metastatic capability of 4T1 and may do so by modulating protease expression.Keywords
This publication has 15 references indexed in Scilit:
- Cathepsin L Gene Expression and Promoter Activation in Rodent Granulosa CellsEndocrinology, 2004
- Pro-Matrix Metalloproteinase-2 Transfection Increases Orthotopic Primary Growth and Experimental Metastasis of MDA-MB-231 Human Breast Cancer Cells in Nude MiceCancer Research, 2004
- A dual role for tumor-derived chemokine RANTES (CCL5)Immunology Letters, 2003
- Respiratory syncytial virus‐induced CCL5/RANTES contributes to exacerbation of allergic airway inflammationEuropean Journal of Immunology, 2003
- Selective suppression of cathepsin L by antisense cDNA impairs human brain tumor cell invasion in vitro and promotes apoptosisCancer Gene Therapy, 2003
- CHEMOKINES AND ANTITUMOR IMMUNITY: WALKING THE TIGHTROPEInternational Reviews of Immunology, 2003
- Decreased activity of cathepsins L + B and decreased invasive ability of PC3 prostate cancer cells.Biotechnic & Histochemistry, 2003
- Chemokines: agents for the immunotherapy of cancer?Nature Reviews Immunology, 2002
- Chemokine Receptor Desensitization in Tumor-Bearing MiceCellular Immunology, 2001
- Matrix MetalloproteinasesJournal of Biological Chemistry, 1999