Silicon-mediated annulation. Part 1. A synthesis of tetrahydropyran-4-ones, oxepan-4-ones, and oxocan-4-ones via intramolecular directed aldol reactions
- 1 January 1985
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- p. 2093-2100
- https://doi.org/10.1039/p19850002093
Abstract
A Lewis acid-catalysed intramolecular directed aldol condensation of enol silanes and acetals was used to prepare tetrahydropyran-4-ones, oxepan-4-ones, and oxocan-4-ones. The course of the cyclisations was influenced by the Lewis acid and the stereochemistry of the starting material.Keywords
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