Biologic properties of bacterial lipopolysaccharides treated with chromium chloride

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Abstract
Addition of small amounts of chromium chloride to a saline suspension of Salmonella typhosa lipopolysaccharide (LPS;Difco) caused a marked reduction in several of the biologic activities of this substance including toxicity, B[bone marrow derived]-cell mitogenicity, plasma colony-stimulating activity (CSA), radioprotective effect and induction of the dermal Shwartzman reaction. LPS treated with chromium chloride was at least as effective as untreated LPS in enhancing resistance of B6CBF1 mice to the lethal effects of Klebsiella pneumoniae infection. [Mice and rabbits were used.].