The use of indirect immunofluorescence flow cytometry for the analysis of erythrocyte antigen. (II).

1 January 1987

journal article
Published by Japan Society of Transfusion Medicine and Cell Therapy in Journal of the Japan Society of Blood Transfusion

Vol. 33 (6) , 702-709
https://doi.org/10.3925/jjtc1958.33.702

Abstract

In the preceding paper, We reported preliminaries of the Rh Zygosity determination by the use of the indirect immunofluorescence Flow Cytometry method (FCM).This report deals with the Zygosity determination of the rare blood -D- and Rhnull by FCM.All cell samples from the parents of the three -D- propositi showed a typically heterozygous pattern for -D- haplotype by FCM.As for the O Rhnull family, FCM of W. O.'s parents showed heterozygous patterns for c, E, D and Hro respectively.The parents of T. S, another Rhnull showed expected patterns for the Rh haplotypes.The results obtained indicated that the propositus of the W. O, Rhnull was due to the amorph Rhnull gene and that of T. S, Rhnull was of the regulator type.

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