Effect of Triton WR-1339 on Lipoproteins and Lipoprotein Lipase of Guinea Pig Plasma
- 1 March 1962
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 109 (3) , 507-509
- https://doi.org/10.3181/00379727-109-27250
Abstract
Administration of Triton WR-1339 to guinea pigs (300 mg/kg) altered plasma lipoproteins so that they were not cleared by guinea pig lipoprotein lipase. Plasma lipoproteins of normal guinea pigs similarly were rendered resistant to lipoprotein lipase by incubation with Triton in vitro. Comparison of plasma lipoprotein lipase levels in Triton-treated and control animals showed that the former group possessed significantly higher levels of enzyme. The mechanism responsible for the Triton-induced hyperlipemia was discussed in view of these findings.Keywords
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