Prolactin release by synthetic luteinizing hormone-releasing hormone (LHRH) in thyroidectomized-androgenized adult rats.

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Abstract
Synthetic LHRH [luteinizing hormone-releasing hormone] at a dose of 5 .mu.g/kg markedly increased serum LH [luteinizing hormone] level but markedly decreased serum prolactin level when injected i.v. to normal adult female rats on the day of estrus. In androgenized adult rats showing persistent estrous vaginal smears, a less marked increase in the serum LH level followed injection of LHRH. Prolactin level decreased only slightly in these animals. Control level of serum prolactin in normal estrous and androgenized rats were 4.95 .+-. 0.35 and 5.42 .+-. 0.65 mIU/ml, respectively. Thyroidectomized-normal cycling rats responded to LHRH with a slight decrease in the serum prolactin level when injected on the day of diestrus. Prolactin level increased 5 min after LHRH injection in thyroidectomized-androgenized adult rats, which were thyroidectomized at age 4, 6 or 10-12 wk and had retained a low prolactin level similar to that in the diestrous stage of normal cycling rats thereafter. The regulatory system of prolactin secretion probably became labile by androgenization, and this status probably let to the release of prolactin by LHRH treatment after thyroidectomy.

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