Studies of Bacterial Throat Flora during Chemoprophylaxis of Rheumatic Fever

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Abstract
THE well established relation between acute rheumatic fever and antecedent infection due to Group A hemolytic streptococci has resulted in the widely accepted use of continuous daily chemoprophylaxis for the prevention of rheumatic fever in susceptible persons. The two agents that have demonstrated the most practical application for such prophylaxis are sulfadiazine and penicillin by mouth, and the use of these drugs has now undergone extensive clinical trial. Many workers have reported a low rate of occurrence of hemolytic streptococcal infections in children receiving chemoprophylaxis,1 2 3 4 5 6 7 8 9 10 11 12 but some questions persist regarding the potential dangers of such continuous prophylaxis.The possibility that . . .