The Spermicidal Powers of Chemical Contraceptives: III. Pessaries

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Abstract
1. A technique is described for comparing the spermicidal powers of pessaries, using human sperms. 2. Those pessaries which do not contain cocoa-butter are more spermicidal than those that do. 3. Quinine and lactic acid pessaries, in cocoa-butter vehicles, are almost without effect upon sperms. 4. There is more than ten times as much quinine bisulphate in a quinine pessary as suffices to kill all sperms in half an hour, but the cocoa-butter prevents its action in some way which is not at present understood. 5. Semori is the most spermicidal pessary of the nine investigated. Even at one-tenth of the concentration at which it is normally used, it kills every sperm or nearly every sperm in half an hour. 6. Even if the foam-producing substances are omitted, semori remains effective. 7. The minute quinine urea hydrochloride pessary is nearly as effective as semori, but the absence of foam-producing substances in this pessary limits its usefulness. 8. Speton relies for its spermicidal power wholly upon its foam-producing substances. Its supposedly active substance, sodium dichlorylsulphamidbenzoate, is without effect upon sperms.

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