Is captopril effective in primary pulmonary hypertension?.

Abstract
Several vasodilating agents have been used for the treatment of primary pulmonary hypertension (PPH). No effective therapy is currently available for this distressful disease. An angiotensin-I converting enzyme inhibitor, captopril, was used for one woman suffering from PPH [primary pulmonary hypertension]. Her initial treatment with furosemide, digoxin and spironolactone showed little effect. Further administration of captopril improved her clinical condition from NYHA [New York Heart Association] IV to II and made it possible to treat her at the out-clinic. No adverse effect was found. Captopril is apparently one of the effective drugs in the treatment of PPH.