Determination of cephalosporins utilising thin-layer chromatography with fluorescamine detection
- 1 January 1985
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 110 (7) , 775-778
- https://doi.org/10.1039/an9851000775
Abstract
A thin-layer chromatographic procedure utilising fluorescamine detection is described for the quantitation of cephradine, cefaclor, cephalexin and cefadroxil. The repeatability, sensitivity and detectability of the method are compared with those for o-phthalaldehyde fluorescence emission and UV absorption measurements on the plate. The applicability of the fluorescamine method to the determination of these cephalosporins in serum, urine and pharmaceutical formulations is discussed.Keywords
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