Self-generated diversity produces “insurance effects” in biofilm communities

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Abstract
Diversity generally protects communities from unstable environmental conditions. This principle, known as the “insurance hypothesis,” has been tested in many different ecosystems. Here we show that the opportunistic pathogenPseudomonas aeruginosaundergoes extensive genetic diversification during short-term growth in biofilm communities. The induced genetic changes are produced by arecA-dependent mechanism and affect multiple traits, including the behavior of the bacteria in biofilms. Some biofilm-derived variants exhibit an increased ability to disseminate, whereas others manifest accelerated biofilm formation. Furthermore, the presence of these functionally diverse bacteria increases the ability of biofilms to resist an environmental stress. These findings suggest that self-generated diversity in biofilms provides a form of biological insurance that can safeguard the community in the face of adverse conditions.