EFFECT OF PERSANTIN ON INTERCORONARY COLLATERAL CIRCULATION AND SURVIVAL DURING GRADUAL EXPERIMENTAL CORONARY OCCLUSION - A PRELIMINARY REPORT

  • 1 January 1962
    • journal article
    • research article
    • Vol. 87  (7) , 336-+
Abstract
Ameroid constrictors were placed around the origins of the circumflex and anterior descending coronary arteries in 25 dogs. A dose of 50 mg Persantin (2,6-bis (2-hydroxethyl)-amino-4,8-bis(l-piperidyl)-pyrimido-(5,4-d)-pyrimidine) was given orally 3 times daily to 12 of the dogs commencing 1 day before the operation. The blood level of Persantin, determined by a fluorometric method, approximated that found in humans from the recommended dose for human subjects. During the experimental period of 3 months, 11 of the 13 control dogs and 6 of the 12 Persantin-treated animals died. Injections of Schlesinger mass in all dogs dying or killed following the test period showed that Persantin significantly accelerated the development of intercoronary anastomoses in the treated dogs. In the surviving animals Persantin appeared to have produced a rich anastomotic network much greater than that seen in the surviving control dogs that were exposed to anoxia only.