Selective head cooling in the dog

Abstract
A preliminary series of 23 experiments is described during which a technique was evolved for rapid and extreme cooling of the brain by an extracorporeal perfusion unit with rewarming of the jugular blood before its return to the systemic circulation, in order to avoid extremely low body temperature. It is possible to carry out hypothermic perfusion of the head for a considerably longer period of time if jugular rewarming is used. Except for deaths due to difficulties unrelated to hypothermia per se, animals subjected to this procedure survived without neurologic deficit or evidence of brain damage. It is proposed to continue these studies in order to learn if this technique may be adapted to specific problems in neurology and neurosurgery in which selective brain hypothermia may be of benefit.

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