Abstract
Cortisone administered orally to one patient and intravenously in another case failed to affect the hyperpyrexia or anhidrosis of heat stroke. Cortisone appears of no value as an antipyretic adjunct in the treatment of heat pyrexia. These findings contrast with the antipyretic effects of adrenocortical hormones in pneumonia, typhoid fever, Rocky Mountain spotted fever, peritonitis, and in certain experimental pyrexias.