Colchicine Teratogenesis in Hamster Embryos.

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Abstract
Intravenous injection of colchicine (10mg/kg) into pregnant hamsters on the 8th day of gestation causes a 50% resorption of embryos and the induction of congenital malformations in some of the survivors. The malformations produced are anophthalmia, exencephaly, skeletal (rib) defects and umbilical hernia. Increasing colchicine to 20 mgm/kg causes a 95% embryonic mortality rate and anophthalmia in the survivors. The natural resistance of the adult golden hamster to colchicine is confirmed in that the dosages of colchicine used in these experiments produced no maternal disease.

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