Ciprofloxacin disk susceptibility tests: interpretive zone size standards for 5-microgram disks

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Abstract
Evaluations of 5-.mu.g ciprofloxacin disk diffusion susceptibility tests were performed independently by 7 different investigators. The results of the separate tests were combined to increase the number of resistant strains in the challenge set of microorganisms. Based on data with 2652 isolates, the following interpretive breakpoints are tentatively proposed for use in ongoing clinical trials of ciprofloxacin: .ltoreq. 15 mm, resistant (MIC [minimum inhibitory concentration] > 2.0 .mu.g/ml); 16-20 mm, intermediate (1.0 < MIC .ltoreq. 2.0 .mu.g/ml); and .gtoreq. 21 mm, susceptible (MIC .ltoreq. 1.0 .mu.g/ml). Disk tests with Streptococcus spp. and with Pseudomonas maltophilia were not reliable; other microorganisms were accurately categorized by the disk diffusion test.

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