Abstract
Experimental neonatal diarrhoea (E.N.D.) was produced in litters of piglets derived from gilts after oral administration at birth of a washed live suspension of an enteropathogenic strain of Escherichia coli belonging to the O149:K91(B), K88ac(L) group. Different litters varied in their susceptibility to the strain; the mortality attributable to E.N.D. was 38 per cent. (20 of 53 piglets) but two of six litters were almost completely resistant to the enteropathogenic strain. This resistance did not appear to be related to a high level of bacterial agglutinins, somatic (O) antibodies or bactericidal activity in the colostrum.

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