Synthetic approaches to versatile hemoprotein model compounds built from porphyrins and peptides
- 1 January 1982
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 7,p. 1441-1448
- https://doi.org/10.1039/p19820001441
Abstract
Several strategies for the preparation of mono- and bi-functional porphyrins (amino and carboxylate) to which oligopeptides can be attached have been investigated. A porphyrinyl amino-acid derivative has been synthesised by coupling a porphyrin monopropionate with phenylalanine methyl ester. Routes to pyrroles bearing butoxycarbonylaminoethyl side-chains via Curtius-type degradations, are described, and their potential for elaboration into porphyrins is discussed. The most promising bifunctional porphyrin with differentially protected amino and carboxylate side-chains was found to be the butoxycarbonylhydrazido methyl ester derivative of mesoporphyrin-II.This publication has 1 reference indexed in Scilit:
- Synthetic sudies related to myoglobin: syntheses of bridged porphyrin systemsJournal of the Chemical Society, Chemical Communications, 1976