Piracetam in the Treatment of Post-Concussional Syndrome

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Abstract
The effect of piracetam, a cyclical derivative of GABA, was compared with that of a placebo in a double-blind study of 60 patients with post-concussional syndrome of 2-12 mo. duration. The daily dose of piracetam was 4800 mg. After 8 wk of treatment piracetam significantly reduced the occurrence and severity of the following symptoms: vertigo, headache, tiredness, decreased alertness, increased sweating and neurasthenic symptoms. No significant effect was observed on the following symptoms: tremor, orthostatic symptoms, and memory disorders. Side-effects were reported by 64% of the patients under piracetam and by 32% under placebo. Piracetam seems to be a promising new drug for the treatment of post-concussional syndrome.

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