Errors in DNA synthesis induced by aflatoxin B1 modification of poly(dC-dG)
- 1 January 1983
- journal article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 4 (5) , 643-646
- https://doi.org/10.1093/carcin/4.5.643
Abstract
Aflatoxin B1 reacts with poly(dC-dG) to form guanine adducts and apurinic sites. Such modification strongly inhibits the template capacity of the polynucleotide and leads to an increase in non-complementary nucleotide incorporation. The template inhibition and induced errors are reduced by mild heat depurination which removes all 7-substituted modifications.Keywords
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