Bilirubin Inhibition of Heme Biosynthesis
- 26 June 1959
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 129 (3365) , 1741-1742
- https://doi.org/10.1126/science.129.3365.1741
Abstract
The conversion of protoporphyrin and iron to heme is catalyzed by a soluble enzyme prepared from rat liver. This reaction is inhibited by bilirubin, and initial kinetic studies suggest that the inhibition is due in part to a competition between protoporphyrin and the bile pigment. Implications of this finding in hyperbilirubinemia are mentioned.Keywords
This publication has 4 references indexed in Scilit:
- An enzyme which catalyzes the insertion of iron into protoporphyrinBiochimica et Biophysica Acta, 1959
- Heme biosynthesis on the incorporation of iron into protoporphyrinBiochimica et Biophysica Acta, 1959
- EXPERIMENTAL STUDIES ON THE PATHOGENESIS OF KERNICTERUSPediatrics, 1957
- THE PORPHYRIN REQUIREMENTS OF HAEMOPHILUS INFLUENZAE AND SOME FUNCTIONS OF THE VINYL AND PROPIONIC ACID SIDE CHAINS OF HEMEThe Journal of general physiology, 1946