Synthesis of pyrido[3,2-d]pyrimidines from 5-aminopyrimidines
- 1 January 1967
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society C: Organic
- p. 1745-1750
- https://doi.org/10.1039/j39670001745
Abstract
5-Aminouracil, 5-amino-2,4-dimethoxypyrimidine, and 5-amino-1,3-dimethyluracil have been caused to react with αβ-unsaturated aldehydes, ethyl ethoxymethylene-malonate and -cyanoacetate, malonates, and 1,3-dicarbonyl compounds. Certain of the products from these reactions cyclised to yield pyrido[3,2-d]pyrimidines. The ease of cyclisation is shown to depend upon the nature of the substituents in both the aliphatic side-chain and in the pyrimidine ring.Keywords
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