Temporal Relationship between Virus and Interferon Biosynthesis in L Cells Infected with Newcastle Disease Virus

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Abstract
The temporal relationship between virus production and interferon biosynthesis was studied in L cells infected with NDV (Roakin strain). The results indicate that this strain of NDV inefficiently replicates progeny virus and that viral directed protein synthesis (hemagglutinin) is significantly depressed in L cells. These latter findings which are in contradistinction to the observations of others who used the Beaudette and Italien strains of NDV, reflect a primary difference in the characteristics of NDV strains. Evidence is also presented which indicates interferon appears very late in the replication cycle of the virus. These data substantiate the notion that interferon is not responsible for the abortive nature of viral replication.

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