Cecal Flora of White Rats on Purified Diet and Its Modification by Succinylsulfathiazole

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Abstract
In a study of the cecal flora of albino rats on the purified diet of Black et al., the largest group counted was found to be the lactobacilli. The coliform group was also present in important numbers and included, in large proportion, coliform species other than true Escherichia coli. Enterococci and yeast-like organisms were less numerous than either the lactobacilli or the coliform bacteria. "Total" counts always exceeded the sum of the group counts, indicating the presence of types, perhaps bacteroides, for which no group count method is yet available. The feeding of a diet containing 0.5% succinylsulfathiazole depressed the coliform and the lacto-bacillus groups. The former, although more sharply affected, showed a tendency toward re-establishment; the latter showed a slower alteration in numbers but a more permanent one. The reduction in numbers of these 2 groups was in part compensated by the increase in numbers of enterococci and yeast-like forms.