Effect of Certain Anti-Arthritic Compounds on the Permeability of Synovial Membrane in the Rabbit

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Abstract
A study of the absorption of phenolsulphonphthalein from the talo-crural joint of the rabbit was made during an investigation of the effect of certain anti-arthritic compounds on the permeability of synovial membrane. Chloroquine phosphate, chlorpromazine, phenylbutazone, sodium salicylate, and sodium aurothiomalate all decreased the permeability of synovial membrane under differing dosage regimes. The decrease in membrane permeability is therefore a common pharmacological property of these anti-arthritic compounds. The implications of these observations and their relationship to the arthritic process are discussed.