Correlation between steroid myopathy and serum lactic dehydrogenase in systemic lupus erythematosus

Publisher Website
Google Scholar
Abstract
Examination of 27 patients with systemic lupus erythematosus (SLE) before treatment showed an elevation of the serum level of lactic dehydrogenase (LDH) in 15 patients. In these patients, the LDH level fell to normal in response to corticosteroid therapy. In 6 of 27 patients, steroid myopathy with elevation of the LDH level developed during corticosteroid therapy. At the same time, there was no or only a slight increase in the creatine phosphokinase level, while the SGOT [serum glutamic oxaloacetic transaminase] and aldolase levels remained normal. The elevated LDH levels gradually returned to normal as the corticosteroid dosages were reduced and the myopathic symptoms disappeared. The measurement of LDH levels appears useful for diagnosis. The subsequent treatment of patients with steroid myopathy in SLE is suggested.

This publication has 4 references indexed in Scilit: