SERIOUS ARSPHENAMINE REACTIONS WITH REFERENCE TO THEIR PREVENTION

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Abstract
In the past five years i have observed six severe accidents following neoarsphenamine therapy. With the exception of case 4 (service of Dr. S. S. Greenbaum), all were in the service of Dr. Henry B. Shmookler. They constitute a unique assortment of cases, representing as they do every type of serious reaction except exfoliative dermatitis, which may, and frequently does, prove rapidly fatal. The literature on the subject is not so opulent as to make the report of these cases merely supernumerary. Especially is this true of complications such as aplastic anemia (case 1) and transverse myelitis (case 5). Indeed, the universal use of the potent arsphenamines invests this subject with a ubiquitous timeliness. The purport of this report is not, however, to augment the literature with additional case records. It is, rather, to review these cases from the standpoint of prevention and to dissipate the fatalistic notion, held by

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