Antipyretic action and catalase activity

Publisher Website
Google Scholar
Abstract
Since many antipyretics can be used to stabilize H2O2 solns., it has been suggested that they may also conceivably interfere with H2O2 metabolism. To test this theory, a number of representative antipyretics were tested for inhibitory activity in the isolated enzyme system, catalase-H2O2. Inhibition was observed with salicylic acid, acetylsalicylic acid and p-hydroxybenzoic acid, but not with acetanilid, phenacetin, antipyrine and quinine, i.e. there was no parallelism with antipyretic activity.

This publication has 0 references indexed in Scilit: