Effect of Insulin on the Healing of Bone Wounds in Albino Rats

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Abstract
A uniform bone wound was made in the left femur of 66 male albino rats. The animals were divided into 2 groups and the experimental group received daily injections of protamine-zinc insulin. Blood sugar determinations confirmed the systemic hypoglycemic effect of the insulin. At the end of the 7 day healing period, all of the surviving animals were sacrificed and their femora dissected out, radiographed, and their breaking strength tested. Histologic studies were also made on some of the animals. No differences in the degree of healing could be detected by any of these methods.