Evidence for α1-adrenoceptor subtype predominance in the rat seminal vesicle
- 1 April 1989
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 41 (4) , 277-278
- https://doi.org/10.1111/j.2042-7158.1989.tb06453.x
Abstract
Noradrenaline (0·6–19 μM and phenylephrine (2–130 μM induced contractions in the rat seminal vesicle that were competitively antagonized by the α1-adrenoceptor-selective antagonist corynanthine (120–920 nM). Yohimbine (60–450 nM), an α2 adrenoceptor-selective antagonist, produced a non-competitive antagonism of noradrenaline responses, suggesting that the responses were not α2-adrenoceptor mediated. It is concluded that the rat seminal vesicle has a predominance of α1-adrenoceptors.This publication has 12 references indexed in Scilit:
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