Cross-species cluster co-conservation: a new method for generating protein interaction networks
Open Access
- 5 September 2007
- journal article
- Published by Springer Nature in Genome Biology
- Vol. 8 (9) , R185
- https://doi.org/10.1186/gb-2007-8-9-r185
Abstract
Co-conservation (phylogenetic profiles) is a well-established method for predicting functional relationships between proteins. Several publicly available databases use this method and additional clustering strategies to develop networks of protein interactions (cluster co-conservation (CCC)). CCC has previously been limited to interactions within a single target species. We have extended CCC to develop protein interaction networks based on co-conservation between protein pairs across multiple species, cross-species cluster co-conservation.Keywords
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