Regulation of oxygen uptake in resting and pentagastrin-stimulated canine stomach

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Abstract
The relation between O2 uptake and blood flow in the isolated dog stomach was investigated under resting conditions and during intraarterial infusion of isoproterenol or pentagastrin. Blood flows above and below control values were achieved by pump perfusion and partial arterial occlusion, respectively. In the resting stomach, O2 uptake increased from 0.4 to 1.5 ml .cntdot. min-1 .cntdot. 100 g-1 as blood flow increased from 4 to 40 ml .cntdot. min-1 .cntdot. 100 g-1 and then remained constant for blood flows up to 100 ml .cntdot. min-1 .cntdot. 100 g-1. Isoproterenol did not significantly alter the relation between O2 uptake and blood flow. In pentagastrin-stimulated stomachs, O2 uptake was maintained at 2.5 ml .cntdot. min-1 .cntdot. 100 g-1 at blood flows between 40-100 ml .cntdot. min-1 .cntdot. 100 g-1 and decreased at blood flows < 40 ml .cntdot. min-1 .cntdot. 100 g-1. Pentagastrin increases oxidative metabolism in the stomach. Despite this increase in O2 consumption with pentagastrin, the general shape of the relation between blood flow and O2 uptake remained the same and was simply displaced vertically above the control data.