A CASE OF NEUROLEPTIC MALIGNANT SYNDROME SUCCESSFULLY TREATED WITH AMANTADINE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 43  (9) , 381-382
Abstract
A paranoid schizophrenic patient developed the neuroleptic malignant syndrome after receiving 3 doses of fluphenazine HCl and 2 doses of thioridazine while he was recovering from major trauma. Treatment with diphenhydramine and benztropine mesylate was ineffective. Administration of amantadine HCl resulted in resolution of all symptoms within 24 h. After 2 days the amantadine was discontinued. The following day, the neuroleptic malignant syndrome appeared. Readministration of amantadine again resulted in prompt remission of symptoms.

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