TREATMENT OF CAMPYLOBACTER PYLORI GASTRITIS - A PILOT-STUDY USING PIRENZEPINE DIHYDROCHLORIDE (GASTROZEPIN) AND 3 FORMULATIONS OF COLLOIDAL BISMUTH SUBCITRATE (DE-NOL)

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  • 26 October 1988
    • journal article
    • research article
    • Vol. 101  (856) , 651-654
Abstract
Antral biopsies were obtained to detect Campylobacter pylori infection in 382 patients referred for gastroscopy. One hundred and seventy four patients (46%) were infected. Infection was strongly associated with histological gastritis (p < 0.001), but there was no association between histological antral gastritis and the appearance of the gastric antrum during gastroscopy. Because it has been suggested that the lower relapse rate for duodenal ulcer following colloidal bismuth subcitrate (CBS) is due to suppression of C. pylori we investigated different formulations and dosing of CBS for their efficacy in clearing C. pylori. Seventy four infected patients were prospectively assigned to therapy with pirenzepine (11 patients) or one of four regimens of CBS; one swallow tablet 4 times a day (11 patients); two swallow tablets twice daily (16 patients); two buffered swallow tablets twice daily (14 patients); or two chew tablets twice daily (22 patients). All patients treated with pirenzepine and one CBS swallow tablet 4 times a day were still infected after treatment. Infection was not detected in 16 patients taking twice daily doses of CBS; 8 (50%), 3 (21%) and 5 (23%) patients taking two standard, buffered or chew tabs twice daily respectively. Improvement of histological gastritis was observed only in those patients apparently cleared of C. pylori (p < 0.01) and this was due to a decrease in polymorphonuclear leukoyctes. Nine patients apparently cleared of the infection were rebiosied 44-137 days following treatment and 6 (66%) were found again to be infected. This study suggests that suppression of C. pylori may vary with the formulation and dosing of CBS. Suppression of infection is associated with improvement in histological gastritis but long term follow up of patients is required to detect infection relapse.